Effect of probiotic supplementation during pregnancy and infancy in preventing atopic dermatitis in children: a Meta analysis / 中国当代儿科杂志

OBJECTIVE@#To systematically review the effect of probiotic supplementation during pregnancy and infancy in preventing atopic dermatitis in children.@*METHODS@#RevMan5.3 was used to perform a Meta analysis of randomized controlled trials on the effect of probiotic supplementation during pregnancy and infancy in preventing atopic dermatitis in children published between January 2008 and May 2018 across the world. A subgroup analysis was conducted according to the type of probiotics for intervention, follow-up time, time of probiotic supplementation, and study areas.@*RESULTS@#A total of 22 articles were selected, with 3 280 cases in the intervention group and 3 281 cases in the control group. The results of pooled effect size showed that probiotic supplementation during pregnancy and/or infancy significantly reduced the incidence rate of atopic dermatitis (RR=0.81, 95%CI: 0.70-0.93, P2 years (RR=0.74, 95%CI: 0.61-0.90, P<0.05); probiotic supplementation had a significant effect in Australia (RR=0.83, 95%CI: 0.73-0.96, P<0.05) and Europe/the United States (RR=0.74, 95%CI: 0.61-0.91, P<0.05). Heterogeneity was mainly due to follow-up time (I=62.7%) and time of probiotic supplementation (I=53.5%).@*CONCLUSIONS@#Probiotic supplementation during pregnancy and infancy helps to prevent atopic dermatitis in children, and mixed Lactobacillus-Bifidobacterium intervention has a better effect.

Preparation and in-vitro evaluation of the shell vaginal ring containing mifepristone / 中国药学杂志

OBJECTIVE: To prepare and in vitro evaluate the shell vaginal ring(VR)containing mifepristone. METHODS: The solid dispersion of mifepristone with PVPK30 as a carrier was prepared and characterized by the methods of differential scanning calorimetry (DSC) and X-ray diffraction analysis (XRD). The shell vaginal ring containing mifepristone was prepared by the method of mold molding process, the inner layer of vaginal ring is the blank silastic skeleton, the middle layer of vaginal ring is the part containing drug, the outermost layer is a non-active silicon rubber membrane. In vitro drug release test was conducted in a dissolution apparatus, release medium was 200 mL PBS (pH 4.0) meeting with sink conditions, and release samples were determined by the UV-vis spectrophotometry. RESULTS: The shell vaginal ring containing mifepristone had a steady drug release rate in vitro during 21 d. The daily release of mifeprisotne was about 1 mg, which sustained two weeks at least at this release rate, and the variance intra- batch was very small. CONCLUSION: The shell vaginal ring containing mifepristone exhibits the sustained and controlled release characteristics in vitro, and the preparation method is stable. The developed UV-vis method is rapid, accurate and convenient.